It is used in combination with other medications to treat heart failure. Lisinopril is also used to improve survival after a heart attack. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. This article discusses lisinopril and why it is prescribed for certain conditions. It explains the main side effects and the dangers of taking lisinopril, as well as possible drug interactions. Lisinopril is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. Lisinopril is an ACE inhibitor. It is used to treat high blood pressure, congestive heart failure in adults, or to improve survival after a heart attack. Lisinopril is an oral medication used to treat high blood pressure and heart failure. Learn about side effects, warnings, dosage, and more. Learn about common and rare lisinopril side effects and what to do if they occur. Find patient medical information for Lisinopril (Prinivil, Zestril, others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings.